Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein
Identifieur interne : 000775 ( Pmc/Checkpoint ); précédent : 000774; suivant : 000776Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein
Auteurs : Chung-Ke Chang [Taïwan] ; Shou-Chen Lo [Taïwan] ; Yong-Sheng Wang [Taïwan] ; Ming-Hon Hou [Taïwan]Source :
- Drug Discovery Today [ 1359-6446 ] ; 2015.
Abstract
Coronavirus nucleocapsid proteins are appealing drug targets against coronavirus-induced diseases. A variety of compounds targeting the coronavirus nucleocapsid protein have been developed. Many of these compounds show potential antiviral activity.
Url:
DOI: 10.1016/j.drudis.2015.11.015
PubMed: 26691874
PubMed Central: 7108309
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein</title><author><name sortKey="Chang, Chung Ke" sort="Chang, Chung Ke" uniqKey="Chang C" first="Chung-Ke" last="Chang">Chung-Ke Chang</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Institute of Biomedical Sciences, Academia Sinica, Nangang, Taipei 11529, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Biomedical Sciences, Academia Sinica, Nangang, Taipei 11529</wicri:regionArea><wicri:noRegion>Taipei 11529</wicri:noRegion></affiliation></author><author><name sortKey="Lo, Shou Chen" sort="Lo, Shou Chen" uniqKey="Lo S" first="Shou-Chen" last="Lo">Shou-Chen Lo</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227</wicri:regionArea><wicri:noRegion>Taichung 40227</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yong Sheng" sort="Wang, Yong Sheng" uniqKey="Wang Y" first="Yong-Sheng" last="Wang">Yong-Sheng Wang</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227</wicri:regionArea><wicri:noRegion>Taichung 40227</wicri:noRegion></affiliation></author><author><name sortKey="Hou, Ming Hon" sort="Hou, Ming Hon" uniqKey="Hou M" first="Ming-Hon" last="Hou">Ming-Hon Hou</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Institute of Genomics and Bioinformatics, National Chung Hsing 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11529</wicri:regionArea><wicri:noRegion>Taipei 11529</wicri:noRegion></affiliation></author><author><name sortKey="Lo, Shou Chen" sort="Lo, Shou Chen" uniqKey="Lo S" first="Shou-Chen" last="Lo">Shou-Chen Lo</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227</wicri:regionArea><wicri:noRegion>Taichung 40227</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yong Sheng" sort="Wang, Yong Sheng" uniqKey="Wang Y" first="Yong-Sheng" last="Wang">Yong-Sheng Wang</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227</wicri:regionArea><wicri:noRegion>Taichung 40227</wicri:noRegion></affiliation></author><author><name sortKey="Hou, Ming Hon" sort="Hou, Ming Hon" uniqKey="Hou M" first="Ming-Hon" last="Hou">Ming-Hon Hou</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227</wicri:regionArea><wicri:noRegion>Taichung 40227</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0015">Biotechnology Center, National Chung Hsing University, Taichung 40227, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Biotechnology Center, National Chung Hsing University, Taichung 40227</wicri:regionArea><wicri:noRegion>Taichung 40227</wicri:noRegion></affiliation></author></analytic><series><title level="j">Drug Discovery Today</title><idno type="ISSN">1359-6446</idno><idno type="eISSN">1878-5832</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Coronavirus nucleocapsid proteins are appealing drug targets against coronavirus-induced diseases.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">A variety of compounds targeting the coronavirus nucleocapsid protein have been developed.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Many of these compounds show potential antiviral activity.</p></list-item></list></p></div></front><back><div1 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Drug Discov Today</journal-id><journal-id journal-id-type="iso-abbrev">Drug Discov. Today</journal-id><journal-title-group><journal-title>Drug Discovery Today</journal-title></journal-title-group><issn pub-type="ppub">1359-6446</issn><issn pub-type="epub">1878-5832</issn><publisher><publisher-name>Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26691874</article-id><article-id pub-id-type="pmc">7108309</article-id><article-id pub-id-type="publisher-id">S1359-6446(15)00450-X</article-id><article-id pub-id-type="doi">10.1016/j.drudis.2015.11.015</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Chang</surname><given-names>Chung-ke</given-names></name><xref rid="aff0005" ref-type="aff">1</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Lo</surname><given-names>Shou-Chen</given-names></name><xref rid="aff0010" ref-type="aff">2</xref></contrib><contrib contrib-type="author" id="aut0015"><name><surname>Wang</surname><given-names>Yong-Sheng</given-names></name><xref rid="aff0010" ref-type="aff">2</xref></contrib><contrib contrib-type="author" id="aut0020"><name><surname>Hou</surname><given-names>Ming-Hon</given-names></name><email>mhho@dragon.nchu.edu.tw</email><xref rid="aff0010" ref-type="aff">2</xref><xref rid="aff0015" ref-type="aff">3</xref><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="aff0005"><label>1</label>Institute of Biomedical Sciences, Academia Sinica, Nangang, Taipei 11529, Taiwan</aff><aff id="aff0010"><label>2</label>Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227, Taiwan</aff><aff id="aff0015"><label>3</label>Biotechnology Center, National Chung Hsing University, Taichung 40227, Taiwan</aff><author-notes><corresp id="cor0005"><label>⁎</label><italic>Corresponding author</italic>:. <email>mhho@dragon.nchu.edu.tw</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>12</day><month>12</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>4</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>12</day><month>12</month><year>2015</year></pub-date><volume>21</volume><issue>4</issue><fpage>562</fpage><lpage>572</lpage><permissions><copyright-statement>Copyright © 2015 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Elsevier Ltd</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="author-highlights" id="abs0005"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Coronavirus nucleocapsid proteins are appealing drug targets against coronavirus-induced diseases.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">A variety of compounds targeting the coronavirus nucleocapsid protein have been developed.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Many of these compounds show potential antiviral activity.</p></list-item></list></p></abstract><abstract id="abs0015"><p>The advent of severe acute respiratory syndrome (SARS) in the 21st century and the recent outbreak of Middle-East respiratory syndrome (MERS) highlight the importance of coronaviruses (CoVs) as human pathogens, emphasizing the need for development of novel antiviral strategies to combat acute respiratory infections caused by CoVs. Recent studies suggest that nucleocapsid (N) proteins from coronaviruses and other viruses can be useful antiviral drug targets against viral infections. This review aims to provide readers with a concise survey of the structural features of coronavirus N proteins and how these features provide insights into structure-based development of therapeutics against coronaviruses. We will also present our latest results on MERS-CoV N protein and its potential as an antiviral drug target.</p></abstract><abstract abstract-type="teaser" id="abs0010"><title>Teaser</title><p>Nucleocapsid proteins are essential for coronavirus viability and constitute potential targets for the development of therapeutics against recent coronavirus outbreaks such as SARS and MERS.</p></abstract></article-meta></front></pmc><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Chang, Chung Ke" sort="Chang, Chung Ke" uniqKey="Chang C" first="Chung-Ke" last="Chang">Chung-Ke Chang</name></noRegion><name sortKey="Hou, Ming Hon" sort="Hou, Ming Hon" uniqKey="Hou M" first="Ming-Hon" last="Hou">Ming-Hon Hou</name><name sortKey="Hou, Ming Hon" sort="Hou, Ming Hon" uniqKey="Hou M" first="Ming-Hon" last="Hou">Ming-Hon Hou</name><name sortKey="Lo, Shou Chen" sort="Lo, Shou Chen" uniqKey="Lo S" first="Shou-Chen" last="Lo">Shou-Chen Lo</name><name sortKey="Wang, Yong Sheng" sort="Wang, Yong Sheng" uniqKey="Wang Y" first="Yong-Sheng" last="Wang">Yong-Sheng Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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